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LIPIDAT: a database of lipid phase transition temperatures and enthalpy changes. DMPC data subset analysis
Chemistry and Physics of Lipids
|March 1, 1992
Summary
A new database, LIPIDAT, centralizes lipid phase behavior data. Analysis of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) reveals trends in research methods and publication frequency over 23 years.
Area of Science:
- Lipidomics and biophysics
- Thermodynamics of lipid phase transitions
Background:
- Lipid mesomorphic and polymorphic phase properties are extensively studied.
- Data on lipid phase behavior are scattered across literature, hindering accessibility.
Purpose of the Study:
- To compile and analyze lipid phase transition data in a centralized database (LIPIDAT).
- To present an analysis of LIPIDAT focusing on fully hydrated 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC).
Main Methods:
- Compilation of mesomorphic and polymorphic phase transition temperatures and enthalpy changes.
- Inclusion of effects of pH, salts, ions, and additives.
- Reporting of experimental methods and conditions.
Main Results:
- LIPIDAT contains ~10,000 records (as of June 1990), with 702 records for DMPC from 1967-1989.
- Research on DMPC shows increasing publication rates peaking in 1977.
- Differential scanning calorimetry, ESR, fluorescence, NMR, and Raman spectroscopy are common DMPC analysis methods.
Conclusions:
- LIPIDAT provides a valuable resource for accessing and analyzing lipid phase behavior data.
- The DMPC subset analysis highlights evolving research trends and popular methodologies in lipid biophysics.