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Related Experiment Videos

Cyanide intoxication in Macaca mulatta. Physiological and neuropathological aspects.

J B Brierley, P F Prior, J Calverley

    Journal of the Neurological Sciences
    |January 1, 1977
    PubMed
    Summary

    This study investigated sodium cyanide

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    Area of Science:

    • Neuroscience
    • Toxicology
    • Physiology

    Background:

    • Sodium cyanide is a potent toxin.
    • Understanding its effects on the central nervous system is crucial.

    Purpose of the Study:

    • To investigate the neurological and physiological effects of intravenous sodium cyanide infusion in M. mulatta.
    • To determine if cyanide poisoning causes purely histotoxic hypoxic neuronal damage.

    Main Methods:

    • Intravenous infusion of sodium cyanide in anesthetized M. mulatta.
    • Monitoring of electroencephalogram (EEG), electrocardiogram (ECG), respiratory rate, blood pressure, and body temperature.
    • Analysis of blood gases, pH, lactate, and pyruvate in arterial and venous sinus blood.

    Main Results:

    • Initial hyperventilation and tetany, followed by apnea with rapid infusion.
    • Cyanide infusion precipitated bradycardia and hypotension, leading to isoelectric EEG.
    • No epileptic seizures were observed.
    • Three animals died from heart failure; four survivors showed white matter brain damage.

    Conclusions:

    • Under these experimental conditions, cyanide poisoning did not result in hypoxic neuronal damage of a purely histotoxic type.
    • Observed brain damage was likely secondary to circulatory complications like hypotension and bradycardia.

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