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Reserpine increases striatal neurotensin mRNA levels
1Department of Histology and Neurobiology, Karolinska Institute, Stockholm, Sweden.
Brain Research. Molecular Brain Research
|February 1, 1992
Summary
Reserpine increases neurotensin (NT) in the striatum. This study found that reserpine boosts neurotensin synthesis by increasing neurotensin mRNA levels in the brain.
Area of Science:
- Neuroscience
- Pharmacology
Background:
- Reserpine administration elevates striatal neurotensin levels.
- This elevation parallels striatal dopamine depletion.
Purpose of the Study:
- To investigate if reserpine treatment enhances striatal neurotensin synthesis.
- To examine the impact of reserpine on neurotensin mRNA expression.
Main Methods:
- In situ hybridization histochemistry was employed.
- Striatal neurotensin messenger RNA (mRNA) levels were quantified.
Main Results:
- Reserpine administration significantly increased the number of striatal cells expressing neurotensin mRNA at 6 hours.
- No significant increase in neurotensin mRNA was observed at 1 hour post-administration.
Conclusions:
- The observed increase in striatal neurotensin tissue levels following reserpine administration is likely partly mediated by enhanced peptide synthesis.
- Reserpine upregulates neurotensin synthesis in the striatum.