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Lomefloxacin concentrations in bone after a single oral dose
A On1, C H Nightingale, R Quintiliani
1Hartford Hospital, Connecticut 06115.
The American Journal of Medicine
|April 6, 1992
Summary
This study shows that a single 400 mg oral dose of lomefloxacin effectively penetrates bone tissue, reaching concentrations above minimum inhibitory levels for susceptible bacteria in osteoarthritis patients.
Area of Science:
- Pharmacology
- Orthopedic Surgery
- Infectious Disease
Background:
- Lomefloxacin is a fluoroquinolone antibiotic.
- Understanding antibiotic penetration into bone is crucial for treating bone infections.
- Osteoarthritis patients undergoing hip replacement provide a model for studying bone drug concentrations.
Purpose of the Study:
- To investigate the bone penetration characteristics of lomefloxacin.
- To determine plasma and bone concentrations of lomefloxacin after oral administration.
- To assess the ratio of bone to plasma concentrations.
Main Methods:
- 30 patients with osteoarthritis undergoing total hip replacement were studied.
- A single oral dose of 400 mg lomefloxacin was administered.
- Bone and plasma samples were collected at various time points (1-12 hours post-dose).
Main Results:
- Peak plasma and bone concentrations were observed at 2 and 3 hours post-dose, respectively.
- Concentrations remained above 1.0 microgram/mL in both plasma and bone at 12 hours.
- The average bone-to-plasma ratio exceeded 0.6 at 2 hours post-dose.
Conclusions:
- A single 400 mg oral dose of lomefloxacin achieves significant bone penetration.
- Achieved bone concentrations are generally above the minimum inhibitory concentrations for susceptible organisms.
- Lomefloxacin shows potential for treating bone infections in orthopedic settings.