Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Quinolone pharmacokinetics in the elderly.

J J Schentag1, T F Goss

  • 1Clinical Pharmacokinetics Laboratory, Millard Fillmore Hospital, State University of New York, School of Pharmacy, Buffalo 14209-1194.

The American Journal of Medicine
|April 6, 1992
PubMed
Summary

Quinolone elimination involves kidney and liver functions. Elderly individuals may experience slight pharmacokinetic changes, but dosage adjustments are typically unnecessary unless significant organ dysfunction is present.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Work productivity among treatment-naïve patients with genotype 1 chronic hepatitis C infection receiving telaprevir combination treatment.

Journal of viral hepatitis·2014
Same author

Impact of organism species on microbial eradication and development of resistance in severe gram-negative pneumonia.

Journal of chemotherapy (Florence, Italy)·2010
Same author

A case series of macrolide treatment failures in community acquired pneumonia.

Journal of chemotherapy (Florence, Italy)·2007
Same author

Pharmacokinetic and pharmacodynamic modelling of antibiotic therapy.

Current opinion in infectious diseases·2006
Same author

Linezolid in the treatment of osteomyelitis: results of compassionate use experience.

Infection·2004
Same author

Pharmacokinetics and metabolism of moxifloxacin.

Drugs of today (Barcelona, Spain : 1998)·2003

Area of Science:

  • Pharmacology
  • Geriatric Medicine
  • Drug Metabolism

Background:

  • Quinolones are eliminated through renal excretion and hepatic metabolism.
  • Dual elimination pathways offer protection against drug accumulation in single-organ dysfunction.
  • Age-related physiological changes can impact drug pharmacokinetics.

Purpose of the Study:

  • To assess the influence of aging on quinolone pharmacokinetics.
  • To determine if dosage adjustments are needed in elderly patients.
  • To differentiate between age-related physiological changes and disease effects on drug elimination.

Main Methods:

  • Review of investigations on quinolone pharmacokinetics in the elderly.
  • Comparison of lomefloxacin pharmacokinetics in younger versus elderly subjects.

Related Experiment Videos

  • Analysis of the relationship between age, renal function, and drug clearance.

    • Main Results:

    • Elderly subjects showed slightly higher lomefloxacin serum concentrations and reduced total, renal, and nonrenal clearance.
    • Reduced renal clearance in the elderly correlates with decreased creatinine clearance.
    • Age-related changes in hepatic function may affect nonrenal clearance, but less precisely than renal clearance.

    Conclusions:

    • Normal age-related physiological changes generally do not necessitate quinolone dosage adjustments in the elderly.
    • Disease-related alterations in renal function are more significant than aging itself for quinolone dosing.
    • Quinolone absorption and pharmacodynamics are largely unaffected by age.