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Herpes simplex virus and human papillomavirus sites correlate with chromosomal breakpoints in human cervical
M De Braekeleer1, C Sreekantaiah, O Haas
1Department of Human Science, Universite du Quebec a Chicoutimi, Canada.
Cancer Genetics and Cytogenetics
|April 1, 1992
Abstract:
The distribution of 1,912 breakpoints observed in a series of 148 cervical cancers was analyzed. Fifty bands were shown to be nonrandomly involved in chromosome structural rearrangements. One hundred thirty-three breaks were noted in bands known to contain a human papillomavirus integration site, and 454 breaks were noted in bands containing a herpes simplex virus breakage site. We suggest that herpes simplex viruses and, possibly, papillomaviruses play an important role in the carcinogenesis and/or development of cytogenetic abnormalities in cervical cancers.