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Fasting hyperbilirubinemia in normal squirrel monkeys.

C E Cornelius1, R A Freedland

  • 1Department of Physiological Sciences, University of California, Davis 95616.

Laboratory Animal Science
|February 1, 1992
PubMed
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Bolivian squirrel monkeys exhibit fasting hyperbilirubinemia, causing yellow plasma, due to increased bilirubin production and reduced hepatic conjugation. This makes them a model for studying Gilbert

Area of Science:

  • Comparative physiology
  • Biochemistry
  • Animal models in biomedical research

Background:

  • Plasma of Bolivian squirrel monkeys is yellow after fasting, unlike Brazilian squirrel monkeys.
  • This yellowing is caused by unconjugated hyperbilirubinemia.
  • Fasting induces physiological changes affecting bilirubin metabolism.

Purpose of the Study:

  • To investigate the mechanisms behind fasting-induced hyperbilirubinemia in Bolivian squirrel monkeys.
  • To explore the role of bilirubin turnover and hepatic conjugation.
  • To establish the Bolivian squirrel monkey as a model for human Gilbert's syndrome.

Main Methods:

  • Comparison of plasma characteristics between Bolivian and Brazilian squirrel monkeys.
  • Analysis of bilirubin turnover and production rates during fasting.

Related Experiment Videos

  • Assessment of hepatic bilirubin UDP-glucuronosyltransferase kinetics (Km and Vm) and UDP-glucuronic acid levels.

    • Main Results:

    • A twofold increase in bilirubin turnover/production rate was observed during a 24-hour fast.
    • Decreased hepatic conjugation potential was noted, characterized by higher Km and lower Vm for bilirubin UDP-glucuronosyltransferase.
    • Elevated steady-state plasma and hepatic bilirubin levels correlated with low hepatic UDP-glucuronic acid during fasting.

    Conclusions:

    • Fasting hyperbilirubinemia in Bolivian squirrel monkeys results from increased bilirubin production and impaired hepatic conjugation.
    • The observed mechanisms highlight rate-limiting steps in bilirubin metabolism.
    • The Bolivian squirrel monkey serves as a valuable animal model for studying Gilbert's syndrome type I.