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Related Experiment Videos

Insulin-like growth factor I receptor gene structure.

A M Abbott1, R Bueno, M T Pedrini

  • 1Elliot P. Joslin Research Laboratory, Joslin Diabetes Center, Boston, MA 02215.

The Journal of Biological Chemistry
|May 25, 1992
PubMed
Summary

Researchers characterized the human insulin-like growth factor I (IGF I) receptor gene, finding it spans 21 exons with significant homology to the insulin receptor gene. This structural insight aids future studies on receptor function and variations.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • The insulin-like growth factor I (IGF I) receptor is crucial for regulating cell growth.
  • Understanding its gene structure is key to deciphering its function and variations.

Purpose of the Study:

  • To isolate and characterize the human IGF I receptor gene.
  • To compare its structure with the insulin receptor gene.

Main Methods:

  • Isolation and characterization of human genomic DNA clones.
  • Restriction analysis and DNA sequencing of overlapping clones.

Main Results:

  • The complete coding sequence of the IGF I receptor gene is contained within 21 exons.
  • The gene shows significant structural homology to the insulin receptor gene in size and exon organization.

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  • No exon analogous to the alternatively spliced exon 11 of the insulin receptor was detected.
  • An alternative internal splice site was identified at the 5' end of exon 14.

    • Conclusions:

    • The characterized structure of the IGF I receptor gene provides a foundation for studying receptor function.
    • This knowledge will aid research into the relationship between insulin and IGF I receptors.
    • It facilitates investigation into the molecular basis of different IGF I receptor forms.