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Functional nerve growth factor receptors on human B lymphocytes. Interaction with IL-2
1Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80224.
Journal of Immunology (Baltimore, Md. : 1950)
|June 1, 1992
Summary
Nerve growth factor (NGF) acts as a B cell growth factor, enhancing human B cell proliferation. NGF also upregulates its own receptor and the IL-2 receptor on B cells, suggesting immune regulatory roles.
Area of Science:
- Immunology
- Cell Biology
- Neuroscience
Background:
- Nerve growth factor (NGF) is known for neurotrophic activity.
- NGF also interacts with immune system cells, including B lymphocytes.
Purpose of the Study:
- To characterize NGF's effects on human B cell proliferation.
- To investigate the regulation of NGF receptor expression on B cells.
Main Methods:
- Analysis of NGF receptor expression on human tonsillar and peripheral blood B cells.
- Assessment of NGF's impact on B cell mitogenesis and proliferation.
- Evaluation of combined effects of NGF with IL-2 and IL-4 on B cell responses.
Main Results:
- NGF receptors are expressed on all B cells and increase upon activation.
- NGF augments the mitogenic effect of Staphylococcus aureus Cowan I strain.
- NGF enhances B cell proliferation, particularly when combined with IL-2, by upregulating receptors for both ligands.
Conclusions:
- Human B lymphocytes express functional NGF receptors.
- NGF plays a role in immune regulation and acts as a B cell growth factor.
- NGF and IL-2 interactions involve reciprocal receptor upregulation on B cells.