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Intraductal Delivery to the Rabbit Mammary Gland
Published on: March 9, 2017
Duct carcinoma in situ: 227 cases without microinvasion
M J Silverstein1, B F Cohlan, E D Gierson
1Breast Center, Van Nuys, California 91405.
European Journal of Cancer (Oxford, England : 1990)
|January 1, 1992
Summary
Mastectomy offers superior local control for ductal carcinoma in situ (DCIS) compared to breast-conserving surgery with radiation, despite similar overall survival rates. Conservative treatments showed higher recurrence rates, with some invasive recurrences observed.
Area of Science:
- Oncology
- Surgical Oncology
- Breast Cancer Research
Background:
- Ductal carcinoma in situ (DCIS) without microinvasion is a non-invasive form of breast cancer.
- Treatment strategies for DCIS range from mastectomy to breast-preserving surgeries with or without radiation therapy.
- The optimal treatment approach for DCIS remains a subject of ongoing clinical investigation.
Purpose of the Study:
- To compare the long-term outcomes of different treatment modalities for ductal carcinoma in situ (DCIS) without microinvasion.
- To evaluate local recurrence rates, disease-free survival, and overall survival based on treatment received.
- To assess the necessity of routine axillary lymph node dissection in DCIS cases.
Main Methods:
- Retrospective analysis of 227 patients with DCIS treated between 1979 and 1990.
- Patients were categorized into three groups: mastectomy, excision plus radiation, and excision alone.
- Outcomes including local recurrence, disease-free survival, and overall survival were tracked and compared.
Main Results:
- Mastectomy group (98 patients) demonstrated a 7-year disease-free survival of 98% with only one local invasive recurrence.
- Excision plus radiation group (103 patients) had a 7-year disease-free survival of 84% with a statistically significant higher rate of local recurrences (10 patients) compared to mastectomy (P=0.038).
- Excision alone group (26 patients) showed a 7-year disease-free survival of 67%, but with limited follow-up data. Axillary node dissections were negative in all 163 cases.
Conclusions:
- Mastectomy provides superior local control for DCIS without microinvasion compared to breast-conserving surgery with radiation therapy.
- Conservative treatments, including excision with radiation, are associated with a statistically significant higher rate of local recurrences.
- Routine axillary lymph node dissection is not recommended for DCIS without microinvasion due to its low metastatic potential.
