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Hodgkin's disease.

R F Jarrett

    Bailliere'S Clinical Haematology
    |January 1, 1992
    PubMed
    Summary
    This summary is machine-generated.

    Epstein-Barr virus (EBV) is linked to Hodgkin's disease (HD) in children and older adults. However, other infectious agents, potentially viruses, may cause HD in young adults.

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    Area of Science:

    • Oncology
    • Virology
    • Epidemiology

    Background:

    • Hodgkin's disease (HD) presents heterogeneous epidemiological features, suggesting varied etiologies across age groups.
    • Risk factors in young adults point towards delayed exposure to infectious agents.
    • Elevated antibody titers to Epstein-Barr virus (EBV) precede HD diagnosis, indicating a potential link.

    Purpose of the Study:

    • To investigate the role of Epstein-Barr virus (EBV) in the pathogenesis of Hodgkin's disease (HD) across different age demographics.
    • To explore potential alternative etiologies for HD in young adults.

    Main Methods:

    • Seroepidemiological studies to assess antibody titers to EBV.
    • Molecular studies analyzing EBV genomes in tumor biopsies.
    • Localization of EBV-infected cells and expression of EBV latent gene products.

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    Main Results:

    • EBV genomes are consistently found in a proportion of HD tumor biopsies, with infected cells being clonal.
    • EBV genomes are localized to Reed-Sternberg cells, and their latent gene products are expressed.
    • The majority of HD samples from patients >50 and <15 years are EBV positive, while <15% of young adults' samples contain detectable EBV DNA.

    Conclusions:

    • EBV plays a significant role in the pathogenesis of HD in children and older adults.
    • Other infectious agents, possibly viruses, are implicated in the development of HD in young adults.