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[Malignant transformation in multiple eccrine spiradenoma].

K Husek1, M Plchová, J Samohýl

  • 1II. Patologicko-anatomický ústav LF MU, Brno.

Ceskoslovenska Patologie
|March 1, 1992
PubMed
Summary
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A rare poorly differentiated eccrine carcinoma developed in a young woman with a history of multiple benign eccrine spiradenomas. Direct transformation from spiradenoma to carcinoma was observed, leading to metastatic disease.

Area of Science:

  • Dermatopathology
  • Oncology

Context:

  • Presents a rare case of poorly differentiated eccrine carcinoma.
  • Highlights a patient with a 20-year history of multiple benign eccrine spiradenomas.

Purpose:

  • To document the development and characteristics of eccrine carcinoma arising from benign spiradenomas.
  • To analyze the histological and immunohistochemical features of the malignant transformation.

Summary:

  • A 6-year-old female developed poorly differentiated eccrine carcinoma with trabecular and papillary structures.
  • Tumor cells exhibited bulky nuclei and prominent nucleoli; immunohistochemistry showed positivity for S-100 protein, CEA, cytokeratin 7, and 18.
  • Direct transformation from pre-existing eccrine spiradenomas to carcinoma was observed, with extensive skin involvement and metastasis to the spine and liver.

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Impact:

  • This case underscores the potential for malignant transformation in long-standing benign eccrine spiradenomas.
  • Provides insights into the histopathological and immunohistochemical markers associated with eccrine carcinoma.
  • Contributes to understanding rare cutaneous malignancies and their progression.