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Solid-phase synthesis of an RNA nucleopeptide fragment from the nucleoprotein of poliovirus
C M Dreef-Tromp1, H van den Elst, J E van den Boogaart
1Gorlaeus Laboratory, Leiden, The Netherlands.
Nucleic Acids Research
|May 25, 1992
Abstract:
The naturally occurring RNA-nucleopeptide H-Ala-Tyr[5'-pUUAAAAC-3']-NH2 is prepared via a solid-phase phosphite triester approach using N-SiOMB/O-TBDMS-protected nucleosides. Preliminary 1H-NMR studies show that the peptidyl unit has a remarkable effect on the conformational behaviour of the RNA moiety in the nucleopeptide.