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Related Experiment Videos

Platelet-derived growth factor in human malignancy.

B J Silver1

  • 1Department of Medicine, Case Western Reserve University, Cleveland, OH.

Biofactors (Oxford, England)
|April 1, 1992
PubMed
Summary
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Platelet-derived growth factor (PDGF) plays a role in cell transformation. While its viral form (v-sis) transforms fibroblasts via autocrine signaling, the role of cellular PDGF (c-sis) in human cancers requires further investigation.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cellular Signaling

Background:

  • Platelet-derived growth factor (PDGF) involvement in cell transformation was noted due to homology between its B chain and the viral sis oncogene (v-sis).
  • v-sis transforms fibroblasts through autocrine growth stimulation, inhibited by anti-PDGF antibodies.
  • Cellular sis (c-sis) gene expression and PDGF-like factors are found in human cancers, but a causative role remains unproven.

Purpose of the Study:

  • To investigate the role of cellular PDGF (c-sis) in human malignancies.
  • To clarify the mechanism of PDGF-mediated transformation in epithelial tumors.

Main Methods:

  • Review of existing studies on v-sis and c-sis transforming activity.
  • Analysis of evidence for autocrine PDGF signaling in fibroblasts and epithelial tumors.

Related Experiment Videos

  • Consideration of intracellular PDGF signaling pathways.

    • Main Results:

    • v-sis transforms fibroblasts via an autocrine mechanism.
    • Evidence for c-sis involvement in human malignancies is less convincing, especially in epithelial tumors lacking surface PDGF receptors.
    • Intracellular co-localization of PDGF precursors and receptors suggests an internal autocrine pathway.

    Conclusions:

    • While PDGF is crucial for fibroblast transformation, its role in human epithelial cancers is less clear.
    • An intracellular autocrine pathway for PDGF signaling may operate independently of secretion.
    • Further research into this internal mechanism in de novo human malignancies is warranted.