[Buschke-Loewenstein's tumor]

Buschke-Loewenstein tumour, also called giant condyloma acuminatum, is located on the external genitalia and in the perineal region. It presents as a craggy, burgeoning and locally invasive mass that looks clinically worrying. Histology shows a classically benign papillomatous proliferation, but transformation into invasive carcinoma occurs in about one-third of the cases. Local penetration and sometimes focal cytological atypias have prompted certain authors to use the term verrucous carcinoma. Virological studies have demonstrated the presence, in some of the tumours analysed, of human papilloma virus type 6 and/or 11 DNA appearing as free episomes non integrated within the cellular genome.