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The Ku complex is modulated in response to viral infection and other cellular changes
J P Quinn1, J Simpson, A R Farina
1MRC Brain Metabolism Unit, Royal Edinburgh Hospital, UK.
Biochimica Et Biophysica Acta
|June 15, 1992
Abstract:
The complex of Ku with DNA is demonstrated to have multiple forms as assayed by gel retardation analysis. In CV1 cells this variation of complex can be modulated in response to viral infection with SV40. By Western blot analysis, a correlation can be made between modification of the complex formed on DNA in response to viral infection with variation of the 85 kDa subunit of Ku. Modification of the 85 kDa subunit can also be seen when cells are exposed to various extracellular stimuli including variation in serum levels, PMA and CaPO4.