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Psoriasis: current concepts and new approaches to therapy
U N Das1, K Vijaykumar, N Madhavi
1Department of Medicine, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, India.
Medical Hypotheses
|May 1, 1992
Summary
Psoriasis involves increased skin cell growth and inflammation, linked to abnormal essential fatty acid metabolism and free radical generation. Essential fatty acids show promise in treating psoriasis by addressing these underlying metabolic issues.
Area of Science:
- Dermatology
- Biochemistry
- Immunology
Background:
- Psoriasis is a common inflammatory skin disorder.
- It involves keratinocyte hyperproliferation, abnormal differentiation, vascular changes, and immune cell infiltration.
- Current understanding links psoriasis to disruptions in essential fatty acid metabolism, free radical generation, and eicosanoid pathways.
Purpose of the Study:
- To investigate the role of essential fatty acid metabolism and free radical generation in psoriasis pathogenesis.
- To explore the potential of essential fatty acids in managing psoriasis and its treatment side-effects.
Main Methods:
- Analysis of free radical generation in psoriasis patients.
- Assessment of essential fatty acid metabolism alterations.
- Evaluation of essential fatty acid efficacy in blocking drug side-effects in vivo.
Main Results:
- Psoriasis patients exhibit increased free radical generation.
- Essential fatty acid metabolism is altered in individuals with psoriasis.
- Essential fatty acids can mitigate in vivo side-effects of anti-cancer drugs.
Conclusions:
- Essential fatty acid metabolism plays a critical role in the development of psoriasis.
- Targeting essential fatty acid metabolism offers a potential therapeutic strategy for psoriasis.
- Essential fatty acids may help manage psoriasis and reduce treatment-related adverse effects.