[Clinical characteristics and typological classification of endogenous depression resistant to treatment]

Overall 47 patients suffering from treatment-resistant endogenous depressions were examined. In accordance with psychopathological manifestations, structure and dynamics of the given conditions, typological differentiation was performed. Three main variants, designated as reactive neurotic, endomorphous vital and heteronomic, were described. Differences were shown between resistant and curable endogenous depressions in terms of some clinical, psychopathological and structural signs. A varying character of treatment response under conditions of routine treatment by antidepressants combined with antioxidants is discussed in different clinical varieties of treatment-resistant endogenous depressions.