Related Experiment Video
Updated: Jul 26, 2026

Animal Models of Depression - Chronic Despair Model (CDM)
Published on: September 23, 2021
[Changes in circadian rhythm of various physiological functions in depression]
Abstract:
Analysis of the daily dynamics of some physiological and psychoemotional characteristics in healthy subjects and depressed patients has demonstrated the patients to have circadian rhythm disorders in functions, namely inversion of the daily gradient with the shift of the function optimum to the second half of the day. The depressed patients manifested a high daily variability of the physiological parameters. It should be mentioned that curable conditions were marked by a higher variability as compared to those resistant to the treatment. The latter circumstance permits regarding the ratio of function variability as a potential predictor.
Related Concept Videos
Circadian Rhythms and Gene Regulation
Circadian Rhythms and Gene Regulation
Depression: Overview
Management of Insomnia
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...

