Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

SAS amplification in soft tissue sarcomas.

S H Smith1, S W Weiss, S A Jankowski

  • 1Department of Pediatrics, University of Michigan Medical Center, Ann Arbor 48109.

Cancer Research
|July 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

East Tennessee Dental Association.

The Dental register·2021
Same author

Atypical Histiocytosis in Red Squirrels (Sciurus vulgaris).

Journal of comparative pathology·2017
Same author

Corrigendum to "Histopathological Characterization of Tail Injury and Traumatic Neuroma Development after Tail Docking in Piglets" [J Comp Pathol 155 (1) (2016) 40-49].

Journal of comparative pathology·2016
Same author

Histopathological Characterization of Tail Injury and Traumatic Neuroma Development after Tail Docking in Piglets.

Journal of comparative pathology·2016
Same author

TNF-α modulates genome-wide redistribution of ΔNp63α/TAp73 and NF-κB cREL interactive binding on TP53 and AP-1 motifs to promote an oncogenic gene program in squamous cancer.

Oncogene·2016
Same author

Anatomical and histological study of the dorsal and ventral nasal conchal bullae in normal horses.

The Veterinary record·2015
Same journal

CDK2 Inhibition Exerts RB-Independent Antitumor Activity in CDK4/6 Inhibitor-Resistant HR+/HER2- Breast Cancer.

Cancer research·2026
Same journal

A Clinically Integrated Pediatric Patient-Derived Xenograft Program Enables Evaluation of Cohort and Patient-Specific Biology and Therapeutic Strategies.

Cancer research·2026
Same journal

Editor's Note: Heterodimerization of Insulin-like Growth Factor Receptor/Epidermal Growth Factor Receptor and Induction of Survivin Expression Counteract the Antitumor Action of Erlotinib.

Cancer research·2026
Same journal

Editor's Note: Deguelin Analogue SH-1242 Inhibits Hsp90 Activity and Exerts Potent Anticancer Efficacy with Limited Neurotoxicity.

Cancer research·2026
Same journal

Retraction: Two Functional Epitopes of Pigment Epithelial-Derived Factor Block Angiogenesis and Induce Differentiation in Prostate Cancer.

Cancer research·2026
Same journal

Editor's Note: Chronic Stress Facilitates Lung Tumorigenesis by Promoting Exocytosis of IGF2 in Lung Epithelial Cells.

Cancer research·2026
See all related articles

Sarcoma amplified sequence (SAS) amplification occurs in malignant fibrous histiocytoma and liposarcomas. This gene amplification is linked to tumors in central body sites, not extremities.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Gene amplification drives increased gene expression in human solid tumors.
  • A novel DNA amplification unit, the sarcoma amplified sequence (SAS) gene, was identified in malignant fibrous histiocytoma.
  • SAS amplification originates from chromosome 12q13-14.

Purpose of the Study:

  • To further characterize SAS amplification in soft tissue sarcomas.
  • To determine the frequency and clinical associations of SAS amplification.

Main Methods:

  • Studied a series of soft tissue sarcomas.
  • Analyzed for the presence of SAS amplification using molecular techniques.

Main Results:

  • SAS amplification was detected in 7 of 22 (32%) malignant fibrous histiocytomas.

Related Experiment Videos

  • SAS amplification was also found in 3 liposarcomas.
  • All tumors exhibiting SAS amplification were located in central body regions (abdominal/inguinal), not extremities.

    • Conclusions:

    • SAS amplification is a frequent event in mesenchymal tumors.
    • SAS amplification is significantly associated with abdominal disease in soft tissue sarcomas.