[Effect of TRH on anti-restraint stress in rats]

Strong stress in response to restraint was observed in rats. In these rats, plasma ACTH increased significantly (P less than 0.001) while T3 and T4 decreased (P less than 0.05). After the rats were injected intraperitoneally with TRH, the plasma ACTH increase was obviously attenuated (P less than 0.001), while T3 INS and GLU increased (P less than 0.05) as compared with control rats. The results indicate that peripheral TRH participates in ACTH regulation during restraint stress.