Related Experiment Video
Updated: Oct 2, 2026

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
Published on: March 8, 2012
Nucleolar organizing regions in human papillomavirus infection and in cervical intraepithelial neoplasia
1Department of Human Biopathology, University La Sapienza of Rome, Italy.
Abstract:
The Ag-NOR staining technique for nucleolar organizer regions (Ag-NORs) was applied to 37 biopsies of the uterine cervix taken from colposcopically abnormal areas. Histological examination of the sections showed that 13 patients had condylomatous lesions without atypia, 15 had CIN I, 4 had CIN II, 3 had CIN III and 2 carcinoma in situ. The mean numbers of Ag-NORs in parabasal and basal cells of squamous epithelium increased progressively from CIN I to CIN III-CIS. There was no significant difference between the Ag-NOR count in condylomatous lesions and CIN I. Significant differences were found between the number of Ag-NORs in condylomatous lesions and in the various grades of CIN. The Ag-NOR technique is useful in the diagnosis of cervical intraepithelial neoplasia and confirms the need to regard condylomata of the uterine cervix as intraepithelial neoplasia grade I and recommend these patients for follow-up.
More Related Videos
Related Concept Videos
The Nucleolus
Additional Subnuclear Structures
The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles, paraspeckles, etc. These nuclear...
Mechanisms of Retrovirus-induced Cancers
Mechanisms of Retrovirus-induced Cancers
Nucleoid
Inhibitors of Virion Maturation and Assembly

