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Multivoxel 1H-MRS of stroke
C C Ford1, R H Griffey, N A Matwiyoff
1Department of Neurology, University of New Mexico School of Medicine, Albuquerque 87131.
Neurology
|July 1, 1992
Summary
Proton magnetic resonance spectroscopy revealed reduced N-acetyl groups in stroke patients, correlating with poorer functional recovery. Lactate accumulation was also detected in some patients following cerebral infarction.
Area of Science:
- Neuroscience
- Biochemistry
- Medical Imaging
Background:
- Proton nuclear magnetic resonance spectroscopy (PNMR) enables noninvasive, in vivo detection of brain metabolites.
- Cerebral infarction and ischemia significantly alter brain metabolite concentrations.
Purpose of the Study:
- To investigate brain metabolite changes in patients with cerebral infarction or ischemia using PNMR.
- To correlate metabolite levels with functional recovery after stroke.
Main Methods:
- Utilized PNMR with a stimulated echo-pulse sequence and chemical shift imaging.
- Acquired spectra from multiple contiguous 4-cc volumes across the ischemic and contralateral hemispheres.
- Studied eight patients diagnosed with cerebral infarction or ischemia.
Main Results:
- Six out of eight patients showed reduced N-acetyl groups (NAG) signal in the stroke area compared to controls.
- Lower NAG to phosphocreatine/creatine ratios correlated with diminished functional recovery.
- Lactate was detected in two patients within the infarcted region 9 and 11 days post-infarction.
Conclusions:
- PNMR is effective for in vivo metabolic assessment in cerebral infarction.
- Reduced NAG levels and altered NAG/phosphocreatine ratios may indicate poor prognosis.
- Lactate accumulation can occur in the subacute and chronic phases following stroke.