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Carcinogenic effects of different nitroso-compounds in Chinese hamsters. II. N-nitrosomorpholine and
Zeitschrift Fur Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology
|May 3, 1976
Abstract:
A total of 320 Chinese hamsters (Cricetulus griseus) (CH) were subcutaneously (s.c.) treated with 1/5, 1/10, or 1/20 LD50 of N-nitrosomorpholine (NM) or N-nitrosopiperidine (NP). In the CH, NM and NP both produced up to a 100% rate of papillomas of the cheek pouch, tongue, pharynx, esophagus and forestomach. Occasionally squamous cell carcinomas also developed in these organs. A high rate of hepatomas was realized by NP.
Insights
N-nitrosomorpholine (NM) and N-nitrosopiperidine (NP) induced high rates of papillomas and squamous cell carcinomas in Chinese hamsters. N-nitrosopiperidine also caused a significant incidence of hepatomas.
Area of Science:
- Toxicology
- Carcinogenesis
- Animal Models
Background:
- N-nitrosomorpholine (NM) and N-nitrosopiperidine (NP) are chemical compounds with known toxicological properties.
- Investigating the carcinogenic potential of these compounds in vivo is crucial for understanding chemical-induced cancers.
Purpose of the Study:
- To evaluate the carcinogenic effects of N-nitrosomorpholine (NM) and N-nitrosopiperidine (NP) in Chinese hamsters (CH).
- To determine the incidence and types of tumors induced by these nitrosamines in various organs.
Main Methods:
- 320 Chinese hamsters (Cricetulus griseus) were subcutaneously administered varying doses (1/5, 1/10, 1/20 LD50) of NM or NP.
- Tumor development was monitored in the cheek pouch, tongue, pharynx, esophagus, forestomach, and liver.
Main Results:
- Both NM and NP induced up to 100% papilloma rates in the cheek pouch, tongue, pharynx, esophagus, and forestomach.
- Squamous cell carcinomas were occasionally observed in the same organs.
- N-nitrosopiperidine (NP) treatment resulted in a high incidence of hepatomas.
Conclusions:
- N-nitrosomorpholine and N-nitrosopiperidine are potent carcinogens in Chinese hamsters, inducing tumors in the oral cavity, esophagus, and forestomach.
- N-nitrosopiperidine exhibits specific hepatocarcinogenic activity in this animal model.
- These findings highlight the risks associated with exposure to these nitrosamine compounds.