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Copper-zinc superoxide dismutase in cerebrospinal fluid: implications for oxygen-radical stress in the central
P M Laboyrie1, R A Roos, H W Verspaget
1Department of Neurology, University Hospital, State University Leiden, The Netherlands.
Clinical Neurology and Neurosurgery
|January 1, 1992
Abstract:
We determined the concentration of copper zinc superoxide dismutase (CuZnSOD) in cerebrospinal fluid (CSF) and plasma of 36 persons without neurological illness or with various central and peripheral nervous system disorders not supposed to generate abnormal radical formation. The CuZnSOD concentration in CSF was significantly higher compared with plasma, suggesting the presence of a high oxygen-radical load on the central nervous system. Our data may be considered to reflect normal values.