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Reversible mental deterioration and neurological disturbances with o,p'-DDD therapy
1Department of Neurology, University Hospital, Leiden, The Netherlands.
Clinical Neurology and Neurosurgery
|January 1, 1992
Abstract:
A patient with serious neurological and neuropsychological side-effects of a 2-year treatment with 1,1-dichloro-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (o,p'-DDD) for adrenal carcinoma showed complete recovery after discontinuation of the drug. Studying a larger number of patients during and after long term treatment with o,p'-DDD is indicated. If results of this report are confirmed, therapy should not be discontinued even if serious side effects occur.