Related Experiment Videos
Synthesis, characterization, cytotoxicity and DNA binding studies of diamminediethyldithiocarbamato-platinum(II)
N Jain1, A K Paul, T S Srivastava
1Department of Chemistry, Indian Institute of Technology, Powai, India.
Journal of Inorganic Biochemistry
|February 1, 1992
Abstract:
A new complex [Pt(NH3)2(ddtc)]NO3.2H2O as a 1:1 electrolyte has been prepared. This was characterized by spectroscopic methods. The electronic absorption spectrum of this complex in water suggests that it has a square planar geometry. The infrared, 1H NMR and x-ray photoelectron spectroscopic studies suggest the bonding of ammonia molecules and diethyldithiocarbamate as bidentate ligand to platinum(II) in this complex. The 50% inhibition value of this complex against P388 lymphocytic leukemia cells is comparable with cisplatin. This complex interacts with calf thymus DNA by coordinate covalent bond.