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Primaquine-induced superoxide production by beta-thalassemic red blood cells
L N Grinberg1, O Shalev, A Goldfarb
1Department of Hematology, Hadassah University Hospital, Jerusalem, Israel.
Biochimica Et Biophysica Acta
|July 7, 1992
Abstract:
Primaquine, a prooxidant antimalarial drug, incubated with human red blood cells (RBC) induced marked superoxide generation in the cells as detected by exogenous cytochrome c reduction. In the presence of primaquine, beta-thalassemic RBC produced significantly more superoxide than normal RBC, thus reflecting the vulnerability of beta-thalassemic cells to oxidative stress.