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A G-rich sequence element common to Dictyostelium genes which differ radically in their patterns of expression
A Ceccarelli1, H J Mahbubani, R Insall
1Clare Hall Laboratories, Imperial Cancer Research Fund, Potters Bar, Herts, England.
Developmental Biology
|July 1, 1992
Abstract:
Removal of a G-rich element from the DIF-inducible, prestalk-, and stalk-specific ecmB gene reduces expression but cell-type specificity is retained. The ecmB element will functionally substitute for a homologous sequence upstream of CP2, a cAMP-inducible gene and is bound by GBF, the factor which interacts with the CP2 G box. These results suggest that the G box may play a similar stimulatory role in these two independently regulated genes where it presumably interacts with different ancillary promoter elements.