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Minimal change nephrotic syndrome revealing solid tumors
A Meyrier1, M Delahousse, P Callard
1Service de Néphrologie, Hôpital Avicenne, Bobigny, France.
Nephron
|January 1, 1992
Summary
Solid tumors can cause nephrotic syndrome in adults. Minimal change disease, often linked to cancer, requires considering malignancy in diagnosis.
Area of Science:
- Nephrology
- Oncology
- Pathology
Background:
- Nephrotic syndrome in adults can be associated with underlying malignancies.
- Minimal change disease (MCD) is a common cause of nephrotic syndrome, typically idiopathic.
Observation:
- Two adult patients presented with nephrotic syndrome and were found to have unsuspected solid tumors: small cell lung carcinoma and breast cancer.
- Renal biopsies revealed minimal change disease without immune complex deposition in both cases.
Findings:
- This study adds to the 14 reported cases of paraneoplastic lipoid nephrosis complicating solid tumors.
- The findings suggest a potential link between tumor products or immune responses and the development of MCD.
Implications:
- Adults with minimal change nephrotic syndrome should be evaluated for underlying solid tumors.
- Further research is needed to elucidate the mechanisms by which tumors induce nephrotic syndrome, focusing on tumor gene products and lymphokine secretion.