Immunocytochemical localization of ubiquitin at human neuromuscular junctions
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P Serdaroglu1, V Askanas, W K Engel
1USC Neuromuscular Center, University of Southern California School of Medicine, Los Angeles 90017.
Neuropathology and Applied Neurobiology
|June 1, 1992
Abstract:
Using several specific monoclonal and polyclonal antibodies, we found that ubiquitin is highly concentrated in the post-synaptic domain of human neuromuscular junctions. The distribution and pattern of ubiquitin immunoreactivity is identical to the localization of bound alpha-bungarotoxin, suggesting that ubiquitin may be involved in post-translational modification or turnover of the acetylcholine receptor or other junctional proteins of the muscle fibre.