Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental hydroxyapatite cement cranioplasty.

P D Costantino1, C D Friedman, K Jones

  • 1Department of Otolaryngology, University of Pittsburgh School of Medicine, Pa.

Plastic and Reconstructive Surgery
|August 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hydroxyapatite cement, a smart biomaterial for craniofacial skeletal tissue engineering.

Surgical technology international·2003
Same author

Current use of bone substitutes in maxillofacial surgery.

Facial plastic surgery : FPS·2002
Same author

Future directions in biomaterial implants and tissue engineering.

Archives of facial plastic surgery·2001
Same author

Sphenoethmoid cerebrospinal fluid leak repair with hydroxyapatite cement.

Archives of otolaryngology--head & neck surgery·2001
Same author

[Surgery of the mediastinum. II].

Laryngo- rhino- otologie·2001
Same author

[Surgery of the mediastinum. I. Mediastinal dissection].

Laryngo- rhino- otologie·2001
Same journal

Building Practical Artificial Intelligence Tools For The Plastic Surgeon: A Step-By-Step Guide To Cowork.

Plastic and reconstructive surgery·2026
Same journal

Interpretation Matters: Common Statistical Pitfalls in Retrospective Surgical Research.

Plastic and reconstructive surgery·2026
Same journal

"Inferior Repositioning of the High-Riding Nipple Using a Parenchymal-Based Flap".

Plastic and reconstructive surgery·2026
Same journal

A Four-Step Strategy for the Treatment of Facial Rhytids: A Focus on Upper Facial Wrinkles.

Plastic and reconstructive surgery·2026
Same journal

Evaluating Long-Term Retention of Fresh-Frozen Costal Cartilage Allograft in An Animal Model.

Plastic and reconstructive surgery·2026
Same journal

Manual extrusion of fat granules for primary thinning of a bulky flap.

Plastic and reconstructive surgery·2026
See all related articles

Hydroxyapatite cement effectively reconstructed critical-sized skull defects in cats, showing good bone replacement and histological tolerance. Further research is warranted for human calvarial reconstruction applications.

Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Regenerative Medicine

Background:

  • Hydroxyapatite cement (HAC) is a biocompatible, calcium phosphate-based material.
  • HAC rapidly sets and converts into a microporous implant in vivo.
  • Critical-sized calvarial defects pose significant reconstructive challenges.

Purpose of the Study:

  • To evaluate the efficacy of HAC for reconstructing critical-sized parietal skull defects in a feline model.
  • To compare the outcomes of using 100% HAC versus a 50% HAC/50% autogenous bone mixture.
  • To assess the histological integration and bone regeneration potential of HAC implants.

Main Methods:

  • Bilateral 2.5-cm-diameter full-thickness parietal skull defects were created in six cats.
  • Defects were reconstructed with either 100% HAC or a 50% HAC/50% bone mixture.

Related Experiment Videos

  • Animals were sacrificed at 6 and 12 months for histological and macroscopic evaluation.
  • Positive (methyl methacrylate) and negative (unreconstructed) controls were included.

    • Main Results:

    • All HAC implants maintained soft tissue contour without infection or structural failure.
    • Histological examination revealed progressive replacement of HAC by new bone and soft tissue.
    • New bone comprised 77.3% of the tissue in HAC defects and 64.7% in HAC-bone mixture defects.
    • Negative controls showed incomplete defect filling, while positive controls exhibited foreign-body reactions.

    Conclusions:

    • Hydroxyapatite cement demonstrates excellent biocompatibility and osteoconductive properties for skull defect reconstruction.
    • HAC facilitates significant new bone formation and integration, suggesting potential for calvarial defect repair.
    • The study supports further investigation into HAC for human applications in full-thickness calvarial reconstruction.