Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Making muscle in mammals.

M Buckingham1

  • 1Molecular Biology Department, Pasteur Institute, Paris, France.

Trends in Genetics : TIG
|April 1, 1992
PubMed
Summary

Classical embryology and molecular genetics reveal how muscle develops. Gene regulation, particularly involving the MyoD family, is key to understanding muscle formation in embryos and fetuses.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Non-Luer needles.

Anaesthesia·2013
Same author

Growth of influenza virus in eggs in the presence of bacterial contamination and streptomycin.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)·2010
Same author

Regulation of skeletal muscle stem cell behavior by Pax3 and Pax7.

Cold Spring Harbor symposia on quantitative biology·2008
Same author

15 The formation of skeletal muscle: from somite to hand.

Journal of anatomy·2006
Same author

The in vivo form of the murine class VI POU protein Emb is larger than that encoded by previously described transcripts.

Gene·2004
Same author

A novel complex regulates cardiac actin gene expression through interaction of Emb, a class VI POU domain protein, MEF2D, and the histone transacetylase p300.

Molecular and cellular biology·2004

Area of Science:

  • Developmental biology
  • Molecular genetics
  • Muscle biology

Background:

  • Classical embryology established foundational concepts of muscle origin.
  • Histological and morphological studies detailed fetal and neonatal muscle maturation.

Purpose of the Study:

  • To integrate classical embryology with modern molecular genetics for a comprehensive understanding of myogenesis.
  • To describe the process of muscle formation using gene regulation principles.

Main Methods:

  • Characterization of muscle structural genes.
  • Discovery and study of the MyoD family of myogenic regulatory factors.
  • Application of molecular tools to study embryonic and fetal myogenesis.

Main Results:

  • Identification of key genes involved in muscle development.
  • Elucidation of the role of the MyoD family in regulating myogenesis.
  • A gene regulatory framework for understanding muscle formation.

Conclusions:

  • Myogenesis can be understood through the lens of gene regulation.
  • Molecular tools provide powerful means to study muscle development in early life stages.

Related Experiment Videos