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Related Experiment Videos

Multiple histamine receptors: properties and functional characteristics.

S J Hill1

  • 1Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham, U.K.

Biochemical Society Transactions
|February 1, 1992
PubMed
Summary

Advances in molecular biology enable the cloning of histamine receptors, paving the way to understand receptor variations and neurotransmitter release mechanisms. Future research may reveal counterparts to invertebrate histamine-gated chloride channels in mammals.

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Area of Science:

  • Molecular biology
  • Neuropharmacology
  • Gastroenterology

Background:

  • Histamine receptors play crucial roles in various physiological processes.
  • Species and tissue heterogeneity exists in histamine receptor binding and function.
  • The H3-receptor's mechanism of action on neurotransmitter release is not fully understood.

Purpose of the Study:

  • To highlight recent advances in histamine receptor gene cloning.
  • To discuss the implications for understanding receptor heterogeneity.
  • To explore the potential mechanisms of H3-receptor signaling and histamine receptors in neuronal function.

Main Methods:

  • Cloning of the H2-receptor gene from canine parietal cells.
  • Anticipated structural identification and cloning of H1- and H3-receptors.

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  • Patch-clamp studies on histamine receptors in invertebrate neurons.

    • Main Results:

    • Successful cloning of the canine H2-receptor gene.
    • Identification of a ligand-gated chloride channel in housefly photoreceptor synapses.
    • Hypothesized G-protein coupling for H3-receptor effector systems.

    Conclusions:

    • Cloning efforts provide tools to investigate histamine receptor heterogeneity.
    • H3-receptor signaling likely involves G-proteins.
    • The possibility of mammalian counterparts to invertebrate histamine-gated chloride channels warrants further investigation.