Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pericapillary rosettes in the human spinal cord.

S Sasaki1, S Maruyama

  • 1Department of Neurology, Tokyo Women's Medical College, Japan.

Acta Neuropathologica
|January 1, 1992
PubMed
Summary

New research identifies pericapillary rosettes (PR) in the human spinal cord, distinct from previously known pericapillary inclusion bodies (PIB). These age-related axonal swellings increase with age, particularly in older adults.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[A case of advanced gastric cancer treated with neoadjuvant chemotherapy of low-dose CPT-11 + CDDP].

Gan to kagaku ryoho. Cancer & chemotherapy·2001
Same author

Down-regulation of IL-12 p40 gene in Plasmodium berghei-infected mice.

Journal of immunology (Baltimore, Md. : 1950)·2001
Same author

Interferon alpha inhibits intrahepatic recurrence in hepatocellular carcinoma with chronic hepatitis C: a pilot study.

Hepatology research : the official journal of the Japan Society of Hepatology·2001
Same author

A comparison of serum leptin concentrations in obese and normal weight Japanese women with regular menstrual cycle.

Journal of nutritional science and vitaminology·2001
Same author

Coexpression of inducible nitric oxide synthase and COX-2 in hepatocellular carcinoma and surrounding liver: possible involvement of COX-2 in the angiogenesis of hepatitis C virus-positive cases.

Clinical cancer research : an official journal of the American Association for Cancer Research·2001
Same author

Mange caused by Sarcoptes scabiei (Acari: Sarcoptidae) in wild raccoon dogs, Nyctereutes procyonoides, in Kanagawa Prefecture, Japan.

The Journal of veterinary medical science·2001

Area of Science:

  • Neuropathology
  • Neuroscience
  • Aging Research

Background:

  • Pericapillary regions of the human spinal cord contain unique structures.
  • Previously identified pericapillary inclusion bodies (PIB) differ from these new findings.

Purpose of the Study:

  • To characterize novel eosinophilic bodies found in the human spinal cord.
  • To differentiate these structures from existing classifications of pericapillary bodies.
  • To investigate the association of these bodies with aging.

Main Methods:

  • Histological examination of human spinal cord tissue.
  • Staining techniques including silver impregnation and anti-neurofilament antibody.
  • Microscopic analysis to identify and characterize pericapillary structures.

Main Results:

  • Identified large eosinophilic bodies, termed pericapillary rosettes (PR), in spinal cord pericapillary regions.
  • PR formation is linked to axonal swelling, indicated by neurofilament accumulation and myelin presence.
  • PR are absent in individuals under 30, increasing with age and prevalent in those over 80, especially in thoracic and lumbar gray matter.

Conclusions:

  • Pericapillary rosettes (PR) are a novel finding in the aging human spinal cord.
  • The development and prevalence of PR are strongly associated with the aging process.
  • PR represent a distinct age-related neuropathological change potentially linked to axonal integrity.

Related Experiment Videos