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Quantitative autoradiography of hemicholinium-3 binding sites in human amygdala
S S Wolf1, H R Brashear, C A Levesque
1Department of Neurology, University of Virginia Health Sciences Center, Charlottesville 22908.
Brain Research
|March 6, 1992
Abstract:
We report the binding properties and subnuclear localization of [3H]hemicholinium-3 binding sites in human amygdala using quantitative autoradiography. Specific binding was saturable and high affinity (apparent Kd 2-11 nM). Binding was highest in the basolateral nucleus which receives dense cholinergic innervation from the basal forebrain. Binding closely approximated acetylcholinesterase reactivity. These data support [3H]hemicholinium-3 as a quantitative marker for cholinergic terminals in human brain.