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Effects of ouabain on contractile response to norepinephrine in isolated rat aorta
H Moromizato1, H Miyagi, M Nakayama
1Department of Pharmacology, School of Medicine, University of the Ryukyus, Okinawa, Japan.
General Pharmacology
|March 1, 1992
Abstract:
1. Inhibition of sodium(Na+), potassium(K+)-ATPase activity was dependent on the concentration of ouabain and inverse to the concentration of potassium ([K+]) in the reaction mixture. 2. Contractility of isolated rat aorta preparation in response to norepinephrine was augmented by ouabain and low [K+]. 3. Results suggest that inhibition of Na+,K(+)-ATPase activity will be correlated with augmentation of vascular contractility maybe through activation of Na(+)-calcium exchange system.