Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 28, 2026

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
08:20

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice

Published on: July 12, 2018

Prolactin as a link between behavioral and immune differences between the Roman rat lines.

N Castanon1, J Dulluc, M le Moal

  • 1Laboratoire de Psychobiologie des Comportements Adaptatifs, INSERM U259-INRA, Université de Bordeaux II, France.

Physiology & Behavior
|June 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

'Limiting climate change' or 'finding substitutes': How does action identification influence meat consumption reduction among young adults?

Appetite·2025
Same author

Tetrahydrobiopterin modulates the behavioral neuroinflammatory response to an LPS challenge in mice.

Brain, behavior, and immunity·2022
Same author

Tetrahydrobioterin (BH4) Pathway: From Metabolism to Neuropsychiatry.

Current neuropharmacology·2020
Same author

A dark-light emergence test: Study at two times of the nycthemeral cycle in four-and twelve-week-old rats.

Behavioural processes·2014
Same author

Antisera against small neurotransmitter-like molecules.

Neurochemistry international·2010
Same author

Spontaneous alternation disturbance after lesions of the ventral mesencephalic tegmentum in the rat.

Neuroscience letters·2009
Same journal

Sex-dependent behavioral and prefrontal BDNF mRNA responses to extinction training and short-term citalopram after fear conditioning in rats.

Physiology & behavior·2026
Same journal

Social instability alters the topography of adolescent and adult social behavior and amygdala function.

Physiology & behavior·2026
Same journal

Mitochondrial remodeling in obesity: mechanistic links to impaired energy metabolism and therapeutic perspectives.

Physiology & behavior·2026
Same journal

Orexinergic and opioidergic receptors interaction in the dentate gyrus of the hippocampus on modulation of formalin-induced inflammatory pain responses in the rat.

Physiology & behavior·2026
Same journal

Combined environmental enrichment and aerobic exercise improve cognitive recovery in male rats after bilateral common carotid artery occlusion.

Physiology & behavior·2026
Same journal

Chronic exposure to artificial light at night dampens rhythms in locomotor activity, metabolism, and sleep in female mice.

Physiology & behavior·2026
See all related articles

Roman high (RHA) and low (RLA)-avoidance rats show behavioral and immune differences. Prolactin levels, not the pituitary-adrenocortical axis, may link these brain-immune system variations in these rat models.

Area of Science:

  • Neuroendocrinology
  • Behavioral Neuroscience
  • Psychoneuroimmunology

Background:

  • Roman high (RHA)- and low (RLA)-avoidance rats are Wistar rat lines selected for active avoidance behavior.
  • These lines exhibit distinct locomotor activity, endocrine reactivity, and immune functions.

Purpose of the Study:

  • To investigate the neuroendocrine characteristics of RHA and RLA rats.
  • To identify potential links between brain function, behavior, and immune responses.

Main Methods:

  • Assessment of basal hypothalamo-pituitary-adrenocortical (HPA) axis activity.
  • Evaluation of HPA axis response to novel environment stress and corticotropin-releasing factor (CRF) challenge.
  • Measurement of stimulated prolactin levels.

More Related Videos

Assessing Cellular Stress and Inflammation in Discrete Oxytocin-secreting Brain Nuclei in the Neonatal Rat Before and After First Colostrum Feeding
09:12

Assessing Cellular Stress and Inflammation in Discrete Oxytocin-secreting Brain Nuclei in the Neonatal Rat Before and After First Colostrum Feeding

Published on: November 14, 2018

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring
09:09

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

Related Experiment Videos

Last Updated: Jun 28, 2026

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
08:20

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice

Published on: July 12, 2018

Assessing Cellular Stress and Inflammation in Discrete Oxytocin-secreting Brain Nuclei in the Neonatal Rat Before and After First Colostrum Feeding
09:12

Assessing Cellular Stress and Inflammation in Discrete Oxytocin-secreting Brain Nuclei in the Neonatal Rat Before and After First Colostrum Feeding

Published on: November 14, 2018

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring
09:09

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

Main Results:

  • No significant differences were found in basal HPA axis activity between RHA and RLA rats.
  • HPA axis responses to stress and CRF challenge did not differ between the lines.
  • Stimulated prolactin levels were significantly higher in the RLA rats compared to RHA rats.

Conclusions:

  • The pituitary-adrenocortical axis does not appear to mediate the behavioral and immune differences between RHA and RLA rats.
  • Elevated prolactin levels in RLA rats suggest a potential role in linking behavioral and immune system variations.
  • These rat lines represent a valuable model for studying brain-immune system interactions.