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Prolactin as a link between behavioral and immune differences between the Roman rat lines.

N Castanon¹, J Dulluc, M le Moal

¹Laboratoire de Psychobiologie des Comportements Adaptatifs, INSERM U259-INRA, Université de Bordeaux II, France.

Physiology & Behavior

|June 1, 1992

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Roman high (RHA) and low (RLA)-avoidance rats show behavioral and immune differences. Prolactin levels, not the pituitary-adrenocortical axis, may link these brain-immune system variations in these rat models.

Area of Science:

Neuroendocrinology
Behavioral Neuroscience
Psychoneuroimmunology

Background:

Roman high (RHA)- and low (RLA)-avoidance rats are Wistar rat lines selected for active avoidance behavior.
These lines exhibit distinct locomotor activity, endocrine reactivity, and immune functions.

Purpose of the Study:

To investigate the neuroendocrine characteristics of RHA and RLA rats.
To identify potential links between brain function, behavior, and immune responses.

Main Methods:

Assessment of basal hypothalamo-pituitary-adrenocortical (HPA) axis activity.
Evaluation of HPA axis response to novel environment stress and corticotropin-releasing factor (CRF) challenge.
Measurement of stimulated prolactin levels.

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Main Results:

No significant differences were found in basal HPA axis activity between RHA and RLA rats.
HPA axis responses to stress and CRF challenge did not differ between the lines.
Stimulated prolactin levels were significantly higher in the RLA rats compared to RHA rats.

Conclusions:

The pituitary-adrenocortical axis does not appear to mediate the behavioral and immune differences between RHA and RLA rats.
Elevated prolactin levels in RLA rats suggest a potential role in linking behavioral and immune system variations.
These rat lines represent a valuable model for studying brain-immune system interactions.