[Influence of thioacetamide on nucleolar apparatus of the liver. Cytophotometric study]

The nucleolus associated chromatin in Feulgen-stained liver cells of TAA treated rats is studied using the Lison cytophotometer. The results indicate that the increase in nucleolar volume in these hepatocytes is accompanied by an increase in Feulgen-DNA contents of the nucleolar apparatus, both in rats treated with a normal standard diet and with a Miller and Price diet. This increase is maximal 2 days after a single dose of 10 mg/100 g body weight and reaches 50 and 25% respectively. These results are discussed with consideration to mitosis, distributional error and the metabolic DNA hypothesis.