Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Vaccination against hepatitis A].

G Giusti1, M Russo

  • 1Istituto di Clinica delle Malattie infettive, I Facoltà di Medicina e Chirurgia, Università, Napoli.

Recenti Progressi in Medicina
|June 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Percutaneous treatment of aortic isthmus atresia with begraft covered stent in a 25 kg children: a case report.

Cardiology in the young·2025
Same author

Experimental and clinical applications and outcomes of using different forms of suction in retrograde intrarenal surgery. Results from a systematic review.

Actas urologicas espanolas·2023
Same author

Editorial Comment.

The Journal of urology·2023
Same author

Evolution of hepatic encephalopathy over time: ecological data from a tertiary referral centre for hepatology.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2022
Same author

Phytotherapy for male luts: What happens then? 10-year research.

Actas urologicas espanolas·2022
Same author

Prototyping a memristive-based device to analyze neuronal excitability.

Biophysical chemistry·2019
Same journal

Recenti progressi in medicina·2026
Same journal

Recenti progressi in medicina·2026
Same journal

Recenti progressi in medicina·2026
Same journal

Recenti progressi in medicina·2026
Same journal

Recenti progressi in medicina·2026
Same journal

Recenti progressi in medicina·2026
See all related articles

Hepatitis A (HAV) infection is declining in Europe, increasing susceptibility in young adults. Inactivated vaccines, like the HM 175 strain, offer a promising public health solution for controlling this viral disease.

Area of Science:

  • Hepatology
  • Virology
  • Public Health

Background:

  • Hepatitis A is a global disease, transmitted via the oral-fecal route, with varying endemicity levels worldwide.
  • Declining Hepatitis A virus (HAV) endemicity in Europe shifts immunity to older generations, increasing susceptibility in adolescents and young adults.
  • Hepatitis A infection presents higher morbidity and mortality in adults compared to children, posing a significant public health concern.

Purpose of the Study:

  • To review the epidemiology of Hepatitis A.
  • To discuss the challenges and progress in Hepatitis A vaccine development.
  • To highlight the importance of vaccination for controlling Hepatitis A.

Main Methods:

  • Review of seroepidemiological surveys on Hepatitis A prevalence.

Related Experiment Videos

  • Analysis of different vaccine production approaches: recombinant, live attenuated, and inactivated.
  • Evaluation of the HM 175 strain inactivated vaccine in human volunteers.

    • Main Results:

    • Hepatitis A endemicity is decreasing in many European countries, including Italy.
    • Recombinant and live-attenuated HAV vaccines face production challenges.
    • An inactivated vaccine (HM 175 strain) has been developed and extensively studied in over 25,000 volunteers.

    Conclusions:

    • Hepatitis A remains a public health issue due to increasing susceptibility in younger populations.
    • Passive immunization with immune serum globulins is not an effective long-term control strategy.
    • Inactivated vaccines represent the most promising approach for controlling Hepatitis A virus (HAV) endemicity.