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IP3 receptor: localization to plasma membrane of T cells and cocapping with the T cell receptor

A A Khan1, J P Steiner, M G Klein

  • 1Johns Hopkins University School of Medicine, Department of Neuroscience, Baltimore, MD 21205.

Science (New York, N.Y.)
|August 7, 1992
PubMed

Immune responses in lymphocytes require cellular accumulation of large amounts of calcium (Ca2+) from extracellular sources. In the T cell tumor line Jurkat, receptors for the Ca(2+)-releasing messenger inositol 1,4,5-trisphosphate (IP3) were localized to the plasma membrane (PM). Capping of the T cell receptor-CD3 complex, which is associated with signal transduction, was accompanied by capping of IP3 receptors. The IP3 receptor on T cells appears to be responsible for the entry of Ca2+ that initiates proliferative responses.

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