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Related Experiment Videos

A recent decrease in the time to development of monomorphous and polymorphous posttransplant lymphoproliferative

E J Alfrey1, A L Friedman, R A Grossman

  • 1Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia 19104.

Transplantation
|August 1, 1992
PubMed
Summary
This summary is machine-generated.

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Posttransplant lymphoproliferative disorder (PTLD) developed significantly faster in recent years. Risk factors include heavy immunosuppression with OKT3, DR matching, and Epstein-Barr Virus infection.

Area of Science:

  • Transplant Immunology
  • Oncology
  • Virology

Background:

  • Posttransplant lymphoproliferative disorder (PTLD) is a serious complication following organ transplantation.
  • The time to PTLD development and associated risk factors have been observed to change over time.

Purpose of the Study:

  • To analyze trends in PTLD development time in a multiorgan transplant program.
  • To identify potential risk factors associated with earlier PTLD onset.

Main Methods:

  • Retrospective analysis of 1622 multiorgan transplants performed between February 1965 and December 1990.
  • Comparison of PTLD incidence and time to development between two distinct time periods (1965-1988 and 1988-1990).

Main Results:

Related Experiment Videos

  • A significant decrease in the mean time to PTLD development was observed in the later period (11 +/- 16 weeks) compared to the earlier period (163 +/- 128 weeks).
  • Early PTLD (within 90 days) was more common in the later period.
  • Potential risk factors identified include OKT3 use, DR matching, and Epstein-Barr Virus (EBV) infection.

    • Conclusions:

    • Recent changes in immunosuppressive protocols may be associated with earlier PTLD development.
    • Heavy immunosuppression (e.g., OKT3), good DR matching, and active EBV infection are hypothesized risk factors.
    • Management strategies should consider graft removal and immunosuppression reduction.