Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Normal cortisol secretion in sickle cell anemia.

S T Saad1, M J Saad

  • 1Department of Clinical Medicine, State University of Campinas, UNICAMP, Brazil.

Tropical and Geographical Medicine
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retraction Note to: L-glutamine supplementation induces insulin resistance in adipose tissue and improves insulin signalling in liver and muscle of rats with diet-induced obesity.

Diabetologia·2017
Same author

Impairment of body mass reduction-associated activation of brown/beige adipose tissue in patients with type 2 diabetes mellitus.

International journal of obesity (2005)·2017
Same author

Modulation of early steps in insulin action in the liver and muscle of epinephrine treated rats.

Endocrine·2010
Same author

The impact of several phenotypic features at diagnosis on survival of patients with myelodysplastic syndromes.

Neoplasma·2010
Same author

Obesity enhances eosinophilic inflammation in a murine model of allergic asthma.

British journal of pharmacology·2010
Same author

Variation of bone marrow CD34+ cell subsets in myelodysplastic syndromes according to who types.

Neoplasma·2009

Sickle cell anemia patients do not show hypocortisolism. A rapid ACTH stimulation test revealed normal basal and stimulated cortisol levels, suggesting the adrenal cortex is unaffected by sickling.

Area of Science:

  • Endocrinology
  • Hematology
  • Pathophysiology

Background:

  • Sickle cell anemia is a genetic blood disorder.
  • Adrenal insufficiency is a potential complication.
  • Previous studies suggested hypocortisolism in sickle cell anemia.

Purpose of the Study:

  • To investigate adrenal gland function in sickle cell anemia patients.
  • To determine if sickle cell anemia causes hypocortisolism.
  • To assess adrenal response to ACTH stimulation.

Main Methods:

  • 14 sickle cell anemia patients and 16 normal controls were enrolled.
  • A rapid ACTH stimulation test was performed.
  • Basal and stimulated cortisol levels were measured at 0, 30, 50, and 120 minutes.

Related Experiment Videos

Main Results:

  • No significant differences in basal or stimulated cortisol levels were found between patients and controls.
  • Cortisol increment after ACTH infusion was similar in both groups.
  • Results contradicted previous reports suggesting hypocortisolism.

Conclusions:

  • Sickle cell anemia does not appear to cause hypocortisolism.
  • The adrenal cortex may be resistant to the sickling phenomenon due to its vascularization.
  • Further sensitive tests confirmed no precocious adrenal gland involvement.