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L-baclofen-sensitive GABAB binding sites in the medial vestibular nucleus localized by immunocytochemistry

G R Holstein1, G P Martinelli, B Cohen

  • 1Department of Neurology, Mount Sinai School of Medicine, New York 10029.

Brain Research
|May 22, 1992
PubMed

L-Baclofen-sensitive GABAB binding sites in the medial vestibular nucleus (MVN) were identified immunocytochemically and visualized ultrastructurally in L-baclofen-preinjected rats and monkeys, using a mouse monoclonal antibody with specificity for the p-chlorophenyl moiety of baclofen. Saline-preinjected animals showed no immunostain. In drug-injected animals, there was evidence for both pre- and postsynaptic GABAergic inhibition in MVN mediated by GABAB receptors. These neural elements could be utilized in control of velocity storage in the vestibulo-ocular reflex.

Keywords:
NASA Discipline NeuroscienceNon-NASA Center

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