Regulation of peripheral-type benzodiazepine receptors following repeated benzodiazepine administration
1Institute of Cellular Biology, Faculty of Medicine, University of Buenos Aires, Argentina.
Abstract:
The effects of chronic benzodiazepine (BZD) treatment on rat peripheral-type benzodiazepine receptors (PBR) were studied. Five days treatment with the PBR ligands RO 5-4864 or diazepam (DZ) up-regulates kidney PBR. In contrast clonazepam, a specific central-type BZD receptor ligand, did not alter 3H-RO 5-4864 binding. Fourteen days administration of DZ produced an up-regulation of kidney and heart PBR and a down-regulation of testicular PBR. The results suggest that chronic BZD exposure differentially regulates PBR in peripheral organs.
More Related Videos
07:16Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
Published on: August 16, 2018
05:17BS3 Chemical Crosslinking Assay: Evaluating the Effect of Chronic Stress on Cell Surface GABAA Receptor Presentation in the Rodent Brain
Published on: May 26, 2023
Related Concept Videos
GPCR Desensitization
Desensitization and Tachyphylaxis
Several...
CNS Depressants: Barbiturates and Benzodiazepines
Anxiolytic Drugs: Benzodiazepines and Buspirone
Sedatives and Hypnotics: Overview
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
Sedatives and Hypnotics Drugs: Benzodiazepines
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...
