Diphenylhydantoin effects on salivary secretion and microsomal calcium accumulation and release

Diphenylhydantoin inhibited calcium uptake into dog submandibular microsomes at concentrations of 0.05 mM and greater but did not affect calcium release; mesantoin and hydroxyphenyl-phenylhydantoin were without effect. Diphenylhydantoin (20 mg/kg) given i.v. significantly reduced, and mesantoin slightly reduced secretion from submandibular and parotid glands, but hydroxyphenyl-phenylhydantoin was without effect. These data suggest that the reduced secretory volume produced by diphenylhydantoin may be related to its effect on transmembrane calcium movements.