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Autoradiographic evidence of opioid binding sites in rat growth plate chondrocytes
M Freire-Garabal1, M T Castaño, A Belmonte
1Department of Pharmacology, Faculty of Medicine, University of Santiago de Compostela, Spain.
Neuroendocrinology
|March 1, 1992
Abstract:
After 125I-beta-endorphin was intravenously injected in rats, an autoradiographic study of distal femur growth plates was performed. Results show a specific binding of the radiolabelled peptide to chondrocytes suggesting the possible existence of an opiate modulation of growth plate physiology.