Related Experiment Video
Updated: Aug 16, 2026

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice
Published on: February 18, 2016
The cocaine experience: refuting the concept of a model psychosis?
1Maudsley Hill Hospital, London, UK.
Abstract:
Eighteen patients admitted to a drug dependency unit for opiate detoxification and who had recently used cocaine were asked to describe the experience based on a questionnaire. A comparison was made with 18 schizophrenic patients who completed the same questionnaire. Results showed a qualitative difference in the subjective phenomena described by the two groups. There appeared to be certain phenomena present in a cocaine induced state which appear to be specific to this state. Amongst these features are: increased intensity of colours, prominence of certain colours in illusions, i.e. red and green, and changes in light intensity. Objects appear to be more vivid and stand out, macropsia and micropsia also seem to occur in this group and paranoia if present is of a transient nature. These particular symptoms do not seem to be characteristic of a schizophrenic illness. This may therefore contradict the idea of a drug induced psychosis (in this case cocaine) as being indistinguishable from schizophrenia (the model psychosis theory).
Related Concept Videos
Drug Abuse and Addiction: Pharmacological Phenomena
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
Psychosis and Antipsychotic Drugs: Overview
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Psychosis: Goals of Pharmacotherapy
Psychological and Sociocultural Causes of Schizophrenia

