Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decoding calcium signals by multifunctional CaM kinase.

H Schulman1, P I Hanson, T Meyer

  • 1Department of Pharmacology, Stanford University School of Medicine, California.

Cell Calcium
|June 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sedimentation rate and suPAR in relation to disease activity and mortality in patients with tuberculosis.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2019
Same author

Tools to discriminate between targets of CK2 vs PLK2/PLK3 acidophilic kinases.

BioTechniques·2015
Same author

CT and US features of cervical lymphadenopathy due to kikuchi's disease.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India·2012
Same author

TDP-43 accumulation in inclusion body myopathy muscle suggests a common pathogenic mechanism with frontotemporal dementia.

Journal of neurology, neurosurgery, and psychiatry·2008
Same author

A proteomic study of serum from children with autism showing differential expression of apolipoproteins and complement proteins.

Molecular psychiatry·2006
Same author

Perinuclear biogenesis of mutant torsin-A inclusions in cultured cells infected with tetracycline-regulated herpes simplex virus type 1 amplicon vectors.

Neuroscience·2004

Calcium/calmodulin-dependent protein kinase (CaM kinase) acts as a crucial cellular signal integrator. Its unique autophosphorylation mechanism allows it to effectively process transient and pulsatile calcium signals, enabling stimulus frequency-dependent activation.

Area of Science:

  • Cellular signaling
  • Molecular biology
  • Biochemistry

Background:

  • Ca2+/calmodulin-dependent protein kinase (CaM kinase) is a key regulator of cellular responses to hormones and neurotransmitters.
  • It plays a vital role in mediating Ca2+ actions in neurotransmitter synthesis, release, carbohydrate metabolism, and cytoskeletal dynamics.

Purpose of the Study:

  • To elucidate the structural and functional properties of CaM kinase that enable its precise response to specific Ca2+ signal characteristics.
  • To understand how CaM kinase decodes transient and pulsatile Ca2+ signals.

Main Methods:

  • The study focuses on the molecular mechanisms of CaM kinase activation and regulation.
  • It examines the role of calmodulin as a Ca2+ sensor and the process of autophosphorylation.

Related Experiment Videos

Main Results:

  • CaM kinase utilizes calmodulin to sense narrow ranges of Ca2+ signals.
  • Autophosphorylation allows the kinase to maintain partial activity after Ca2+ dissociation, creating a Ca2+-independent state.
  • Autophosphorylation also traps calmodulin, potentially enabling frequency-dependent activation in response to pulsatile Ca2+ signals.

Conclusions:

  • CaM kinase possesses sophisticated mechanisms to interpret complex Ca2+ signal dynamics.
  • Its ability to adapt to signal transients and oscillations is critical for cellular information processing.
  • The kinase's unique properties highlight its importance in coordinating cellular functions.