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Na+K+ATPase activity and ouabain binding sites in erythrocytes in hyperthyroidism before and after treatment
1Centro per le Malattie Endocrine e Metaboliche Ospedale Civile Umberto I, Mestre-Venezia, Italy.
Journal of Endocrinological Investigation
|May 1, 1992
Abstract:
Erythrocyte sodium pump is decreased in hyperthyroid patients. We described the effect of untreated hyperthyroidism on Na+K+ATPase activity, ouabain binding sites and intracellular sodium concentration. We found a reduction in Na+K+ATPase activity and in number of ouabain binding sites with a concomitant increase in intracellular sodium. B-blockade therapy failed to restore normal pump activity and sodium concentration, where only thionamide treatment was successful when it was able to decrease free T3.